Principles of Molecular Medicine

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Principles of Molecular Medicine

Book: Hardcover 13 - 07 - 1998

Product ID: 4436095

Condition: New
  • Used Book in Good Condition

Publisher : Brand: Humana Press

ISBN-10 : 0896035298

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Product Description This is the first major textbook of molecular medicine to integrate the newest findings from cell and molecular biology with the basic principles of internal medicine. J. Larry Jameson, MD and his authoritative contributors, many of them world-renowned clinicians and researchers, expand the envelope of clinical understanding to encompass a wide array of disciplines-including neurology, cardiology, hematology, nephrology, genetics, endocrinology, oncology, dermatology, psychiatry, and infectious diseases-revealing the underlying molecular mechanisms of disease, as well as the routes to unprecedented novel medicines and treatments now emerging from the new molecular approaches. Here physicians will find informative updates in both their own specialties and in disciplines they may not have been able to follow closely. They will also gain a fuller understanding of the role played by genetic defects in a host of diseases, among them peripheral neuropathies, Alzheimer's disease, arrhythmias, leukemias and lymphomas, cystic fibrosis, hepatitis, HIV, autoimmune disorders, polycystic kidney disease, schizophrenia, affective disorders, alcoholism, Huntington's disease, and many more. This groundbreaking and uniquely valuable new approach to human medical biology will provide practicing physicians, medical students, and researchers alike with a powerful new account of internal medicine and help them to better understand the future of medicine. From The New England Journal of Medicine Debates are taking place in medical schools and on the pages of medical journals about the extent to which medical students need to learn about molecular medicine and about how the subject should be taught. Indeed, the rapid proliferation of modern molecular and genetic techniques and advances in structural biology have made an enormous contribution to our understanding of biologic processes and the mechanisms of disease. Advances in human genetics, immunology, virology, hematology, neurology, drug design, and gene therapy, along with knowledge and applications generated by the Human Genome Project, are converging to create the new interdisciplinary field known as molecular medicine. Molecular medicine promises to transform medical practice by providing new and more efficient approaches to the diagnosis, prevention, and treatment of a wide spectrum of congenital and acquired disorders. We are already seeing the first fruits of these efforts: several recombinant proteins are on the market, some gene-therapy protocols are undergoing phase 3 clinical trials, and a number of molecular diagnostic kits are now available commercially. Because molecular medicine has already started to become an integral part of medical practice, there is a growing need to integrate it into the medical school curriculum and medical education in general. Principles of Molecular Medicine is well suited to serving this purpose, dealing with the more recent molecular and genetic advances in each major branch of medicine and closing the gap between basic science and the bedside. The book is organized according to organ systems and comprises more than 120 chapters, each written by outstanding specialists. It opens with a series of chapters that introduce the seminal molecular and cellular concepts of modern biology and genetics -- the fundamental principles underlying the organization of the human genome, the transcriptional control of gene expression, and the transmission of human genetic diseases. Other chapters describe the tools and techniques available to characterize genes and mutations and to analyze both their expression and their molecular and cellular pathology. The various facets of human hereditary disorders, including genetic counseling and molecular diagnostic testing, are clearly and comprehensively presented. The specialty sections are divided into chapters that, in addition to providing information on the molecular mechanisms of the respec

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